Topic Title: alchol and sjw
| |  "alchol and sjw"
, Sat 2 Aug 14:16
I used to take my sjw and spread it throughout the day but now i take all three at night, because they leave me drowsy and it's a cure for my insomnia. But i noticed something strange a few days ago, i got extremely drunk, then i took all three of my sjw and when i woke up in the moring i felt really high throughout the whole day, and i felt really blissful. Although i'm not carrying this on because alchol is extremely bad for you unless in moderation. But i find it weird because alchol is a depressant, and mixing depressants with anti depressants usually cause horrible effects.
Posts: 1 | | Registered: Tue 22 Jul 2003 11:45 |
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| | "Re(1):alchol and sjw" , Sat 2 Aug 18:51
As far a I understand, SJW exhibits SSRI properties... Whenever I've been on an SSRI and have decreased my dosage, I've always felt almost euphoric for a day or two. I surmise it's because the serotonin I've built up is being consumed really fast...
Alcohol typically neutralizes/counteracts SSRIs - maybe it's the same as decreasing dosage? (?)
Posts: 18 | | Registered: Wed 25 Jun 2003 19:8 |
| | | "alcohol and SJW" , Thu 2 Oct 19:31
Also, SJW has been shown to reduce desire for alcohol in lab experiments with rats. It could be that it does this by improving an organisms overall mood, or it could be that it increases the impact of alcohol so that less is needed to achieve the same effect.
Posts: 3 | | Registered: Thu 2 Oct 2003 17:20 |
| | | "Not really a SSRI" , Thu 2 Oct 19:29
SJW has several compounds and several modes of action. SJW is not a SSRI ... it works on many neurotransmitters, not specifically on serotonin. Here's an abstract that contains the best overview of what we know:
Mechanism of action of St John's wort in depression : what is known? Butterweck V. Institute of Pharmacology and Toxicology, Universitatsklinikum Munster, Munster, Germany. [email protected]
Extracts of Hypericum perforatum L. (St John's wort) are now successfully competing for status as a standard antidepressant therapy. Because of this, great effort has been devoted to identifying the active antidepressant compounds in the extract. From a phytochemical point of view, St John's wort is one of the best-investigated medicinal plants. A series of bioactive compounds has been detected in the crude material, namely flavonol derivatives, biflavones, proanthocyanidines, xanthones, phloroglucinols and naphthodianthrones. Although St John's wort has been subjected to extensive scientific studies in the last decade, there are still many open questions about its pharmacology and mechanism of action. Initial biochemical studies reported that St John's wort is only a weak inhibitor of monoamine oxidase-A and -B activity but that it inhibits the synaptosomal uptake of serotonin, dopamine and noradrenaline (norepinephrine) with approximately equal affinity. However, other in vitro binding assays carried out using St John's wort extract demonstrated significant affinity for adenosine, GABA(A), GABA(B) and glutamate receptors. In vivo St John's wort extract leads to a downregulation of beta-adrenergic receptors and an upregulation of serotonin 5-HT(2) receptors in the rat frontal cortex and causes changes in neurotransmitter concentrations in brain areas that are implicated in depression. In studies using the rat forced swimming test, an animal model of depression, St John's wort extracts induced a significant reduction of immobility. In other experimental models of depression, including acute and chronic forms of escape deficit induced by stressors, St John's wort extract was shown to protect rats from the consequences of unavoidable stress. Recent neuroendocrine studies suggest that St John's wort is involved in the regulation of genes that control hypothalamic-pituitary-adrenal axis function. With regard to the antidepressant effects of St John's wort extract, many of the pharmacological activities appear to be attributable to the naphthodianthrone hypericin, the phloroglucinol derivative hyperforin and several flavonoids. This review integrates new findings of possible mechanisms that may underlie the antidepressant action of St John's wort and its active constituents with a large body of existing literature.
Posts: 2 | | Registered: Thu 2 Oct 2003 17:20 |
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