Topic Title: dosing schedules / hyperforin
| |  "dosing schedules / hyperforin"
, Mon 14 Apr 07:08
I am 5 days into my 1st ever go on the wort, thanks to reading some very interesting posts on here (Thankyou all). I have recently done a lot of research on SJW on the web , and what is most apparent from recent studies is that HYPERFORIN is the main antidepressant constituent in SJW...although there seems to be some ''whole herb'' effect too. What was a little worrying is that from the research done , it has been found that the 'half life' of hyperforin is only 9 hours , and it has a 'residence' of 12 hours. What this means in simple terms is that hyperforin only stays active in your body for a maximum of 12 hours , which brings into question the ''once daily '' dosing schedule. It would seem from this that the original 3 X daily suggestion was probably the best way to ensure constant results.Hyperforin is said to have a 50% blockade of serotonin receptors(feel good chemicals).Another word of caution from personal experience.....AVOID aspartame at all costs .This naughty little sweetener can prevent the body from absorbing serotonin and is especially bad in depressed people . One study had to be abandoned because of the adverse effects on mood on depressed people. I personally experienced this after drinking a diet coke and being unable to sleep for the next few nights. lots of stuff on the internet on ''aspartame and depression ''. Enough of my insane ramblings (hee hee)....take care all , and remember....sunshine increases serotonin .
Posts: 0 | | Registered: Mon 14 Apr 2003 6:55 |
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| |  "Re(1):dosing schedules / hyperforin"
, Sat 19 Apr 08:24
That's a little quirk I have with SJW. I know sunshine is good, it makes you feel good. I like to be out in it. Though on SJW in can be somewhat dangerous to you. Can kinda limit outdoor activities if your doing any. Which I would like to be able to this summer so I'm keeping an open mind toward any alternatives.
Posts: 6 | | Registered: Sun 13 Apr 2003 1:44 |
| | | "Re(2):dosing schedules / hyperforin" , Sat 19 Apr 15:34
I wouldn't say SJW + sunshine is dangerous, in fact it's a rather misunderstood area. Occasionally some people experience a photsensitive rash, but this is the exception rather than the rule. It's more of annoyance than a danger for those people.
Epyx
Posts: 514 | | Registered: Mon 3 Dec 2001 22:11 |
| | "Re(1):dosing schedules / hyperforin" , Sat 19 Apr 08:20
Posts: 5 | | Registered: Sun 13 Apr 2003 1:44 |
| | "Re(1):dosing schedules / hyperforin" , Mon 14 Apr 14:47
Johnny, could you point me to any links about half-life? I've always been under the impression that the half-life of SJW was considered to be around 24-26 hours. I would be interested to discover late research on this point.
Epyx
Posts: 513 | | Registered: Mon 3 Dec 2001 22:11 |
| | | "Re(2):dosing schedules / hyperforin" , Tue 15 Apr 03:03
hi Epyx, thanks for your reply. In answer to your question ,the half life of the hypericins within SJW are 24 hours or so (as you said). The latest research is on one of the other constituents (hyperforin), of which the half life is much shorter. This is the only constituent within SJW which has been shown to block serotonin re-uptake (much like prozac), and it does this with an efficiency of 50%. for info, checkout this website..... www.dietandbody.com/alternativemedicine / article1027.html ......keep well .
Posts: 1 | | Registered: Mon 14 Apr 2003 6:55 |
| | | "Re(3):dosing schedules / hyperforin" , Sat 19 Apr 16:21
Thanks Johnny, that's Camilla Cracchiolo's SJW FAQ. She is a registered nurse who wrote the most informative FAQ document about this herb, but sadly she hasn't updated it for about 6 months and her homepage has been down ever since. I hope she resurrects it.
The half-life of hyperforin does indeed appear to be around 9 hours according to the Biber study, much shorter than for the hypericin family. I guess this will change how some of us look at our dosing schedule. I've been taking 2 in the morning and 1 in the evening, which works for me, so I don't think I'll change ... nah, what the hell, I'll give it a shot!
Epyx
Posts: 516 | | Registered: Mon 3 Dec 2001 22:11 |
| | | "Re(2):dosing schedules / hyperforin" , Mon 14 Apr 20:55
In the beginning I would take the entire dose of SJW in the morning or at night. However, I found that by taking it in 3 doses spread out throughout the day I get a better result. It may not make as much diference now since I have it in my system, but I did not know that SJW can deteriorate in the system rapidly as you say. That may partially explain why it works better to divide the dose. I have to divide the dose anyway now because I have been taking 1,800 mg a day. Today I took 2,100. It might upset my stomach to take that much all at once.
Best regards,
John-
Posts: 2 | | Registered: Sun 13 Apr 2003 0:7 |
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