Topic Title: serotonin & Heart disease
| |  "serotonin & Heart disease"
, Thu 23 May 02:37
Here is an interesting story:
http://www.life-enhancement.com/displayart.asp?ID=53
MJ DuPont
http://events.diabetes.org/memberpages/peshka
Posts: 344 | | Registered: Wed 20 Jun 2001 6:19 |
| |
| | "Re(1):serotonin & Heart disease" , Sat 25 May 22:04
do a search for serotonin heart disease in altavista.com - having it in your blood in excess REALLY does cause it... and 5HTP raises blood serotonin levels...
Posts: 75 | | Registered: Tue 29 Jan 2002 19:58 |
| | | "Re(2):serotonin & Heart disease" , Sun 26 May 04:44:
http://www.erowid.org/smarts/tryptophan/tryptophan_info1.shtml
from this link:
. If 5-HTP never crossed the blood/brain barrier it wouldn't cause the effects it's noted for.
I did a little digging in medline and what I found in published papers is that:
1) Serotonin (or acetylcholine) applied *directly to the heart* can cause heart spasms.
2) There are, however, no reports of this happening due to 5-HTP usage, and the blood concentrations involved would have to be incredibly high.
3) Human studies at doses of 400mg / day of 5-HTP find no serious side effects, and only a ~20% incidence of "mild, transitory" side effects.
4) Animal studies show the first toxicity of 5-HTP at around 1000mg (scaled for human bodyweight), with diahhrea a common side effect. Death is first noted in dogs around the human equivalent of 10,000 mg.
...
Okay, after more digging I can pretty comfortably say that out of the 3700 published papers in MEDLINE that mention 5-HTP, none of them links 5-HTP usage to heart spasms or cardiac arrest. In fact, to the contrary, there are studies that show a protective effect of 5-HTP against fibrillation. Search terms I used: "5-htp" + one of: "heart" "cardiac" "danger" "risk" "safety" "tolerance" "coronary" "spasm" "SD50"
The only studies that I can find that show serotonin causing coronary spasms are when high concentrations of serotonin are injected directly into the heart or one of its chambers, or when another drug or pre-existing syndrome made the heart hypersensitive to serotonin. My survey of this literature has not been as comprehensive, as there are many more papers.
In addition, studies at 800-900mg/day in humans have never found a life threatening or otherwise serious side-effect. Many mild side effects at these dosages have been found. After the dosage is decreased, they go away.
MJ DuPont
http://events.diabetes.org/memberpages/peshka
[this message was edited by DuPont on Sun 26 May 05:24]
Posts: 350 | | Registered: Wed 20 Jun 2001 6:19 |
| | | "also" , Sun 26 May 07:23:
As for the information about increased serotonin levels and the resulting heart problems from phen-fen and redux, the blood levels of serotonin must have been extremely high because
there had been three parts to to the diet pill action: serotonin release; an uptake inhibitor to keep the released serotonin in the bloodstream; and, last, an MAO inhibitor, to hold it all in a while longer. By taking just sjw or 5htp we do not even come close to those levels of serotonin in the blood.
MJ DuPont
http://events.diabetes.org/memberpages/peshka
[this message was edited by DuPont on Sun 26 May 07:28]
Posts: 351 | | Registered: Wed 20 Jun 2001 6:19 |
| | | "Re(1):also" , Tue 28 May 04:55
Hiya Dupont,
Thank you for your research and your posting.
Hope you are still well.
I am going through a split up with my partner at the moment and things are hard but I am finding the 5-HTP is really helping me stay on a level playing field.
I have also been reading some of Susan Jeffers books ie. "feel the fear and do it anyway" and "Embracing Uncertainty". I would certainly highly recommend both books.
Cheers
Nicky :>)
Posts: 40 | | Registered: Thu 7 Feb 2002 5:45 |
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