too much seratonin = depression?

[roy100]

I read something about taking 5htp at the same time with other
Antidepressants (http://rds.yahoo.com/_ylt=A0oGkkWOiQxF0AMBaMVXNyoA;_ylu=X3oDMTE0bjJncDl nBGNvbG8DdwRwb3MDMQRzZWMDb3YtdG9wBHZ0aWQDaTAyMV80N w--/SIG=1kr6lht11/EXP=1158535950/**http%3a//www11.overture.com/d/sr/%3fxargs=15KPjg19ZSn5Xyl%255FruNLbXU6TFhUBf3cDmo5c qXo8qQIhBpCctE7U8LfqexdopH7MiqhGIkrX7qPhDb%252D2h2 7uFUFvPOwLPYLfq3%255FjH04koNKnyCo12t8xxkr692tUcfis EZ26nLd%252D9l%252DzMNoX0PnZC%255FY8DxB2a%252Duc7z LvEwOMXFLLe0Vp%255FjiqnVO4Su60tgczDP%252DlRCb9UftC YmiWXcJVCwsotneykTSgSICuk4xkEo130JkVp%252DKPNLL85q LTx7v2QH%252Dr4nqxdfR6e%255FOI45R%252DWzH2auIIVICa PirpfmVYSFqb4fUSCyk93vvDS3ayfcDxKjiL%252DF4jPSHz2Y VxzYkxvU6ToKhLTJXd871fWK8oZHo3xpX%255FsUfPpTnV2IAB ZgJb3LocL4huL0PZeO0jcS8yXrSw9MOJuzxvjp3%252DC%255F FN4j%252DAi%252D%255FGafcRAz9zaygGdFywE%255FETJ2PX vXKXD7k6s1CEyz8I6VttbgLhfoAlzmw%252E%252E%26yargs= www.cymbalta.com) could build up and give to much seratonin , would not give you Seratonin syndrome , but depression.

I am taking now Remeron 22.5 mg, and 5htp 50 mg, but started a couple of days with 300 mg, , and a couple 150, and decided to stay on 50 mg for 5 days= 9 days , I reduced the dosage because I did not see any change.

I feel a bit down, the The PDr told me to increase my dosage of Remeron from 15 to 30 mg but, just added to 22.5 mg, because it makes me numb, and I feel my head Poufed and I feel my eyes poping out.

How can you tell the difference between the original depression , and depression caused by too much seratonin.

I really doubt I might have to much of it, probably lack of it ......
Thanks , roy

[orlando]

5htp can and does make depression symptoms much worse in certain people. It did have that effect on me and it took me 3 days to get back to my normal i-can-live-with-it depression level. Now, L-Tryptophan is something else. Much better than 5htp against depression and anxiety. More expensive, but it works as it should.

[sfe]

I think too much 5-htp make anxiety but not depression

[orlando]

You cannot deny the experience of others. 5htp did make my depression extremely worse.

I think too much 5-htp make anxiety but not depression

[Quest]

I think that it is important to note that everyone here is right.
5HTP CAN make you worse if serotonin is not low in you to begin with, and say the root of your depression is low dopamine or magnesium or hypoglycemia etc.
However, it WILL most likely, and Im not saying definately, help if indeed low serotonin is the problem. Low serotonin causes depression AND anxiety, too much serotonin can cause anxiety. Its a balance.
For people with anxiety and or depression any one of the many alternatives may work. It depends on the root cause of the depression.

[ChristinaC]

I started taking 5htp about a week ago for anxiety and depression, and after I took it, I felt great and full of energy that first day. I had taken 100mg after dinner, and did the same the next day.
Unfortunatley, after I took that second pill the next day, I had so much anxiety I couldn't sleep and my heart was beating like crazy and I felt 10 times worse than I had before.
Right now I'm just limititing my dose to one pill every few days, and it's working pretty well so far..

[xtrecoolx]

Hi,
This is my first post in this great forum and would like to ask something about what I've realized in this discussion:
Is there any way to determine which transmitter is low in the brain? An EMR or blood test maybe?

[artur]

well i would use the quickest way: self observation. it is probably realy expensive to go through tests, aspecially if you are from US. the most likely neurotransmitters that are associated with depression are seratonin and dompamine. Dopamine is responsible for desire, confidence, how social you are, and so on. seratonin is responsible for appetite, mood, sleep, etc. now if ur low on yourself, shy, dont have desire to do fun activities and feel worthless then its your dopamine. if you stuff yourself with food, feel depressed, have bad sleeping cycles etc, then its your seratonin. but why not improve both? there are amino acids for both of them. Tyrosine produces three neurotransmiters: neropinephrine, DOPAMINE, and epinophrine. 5HTP produces SERATONIN. i take 3-5 grams of tyrosine in the morning on an empty stomache. and i take 100mg of 5htp at night. it works perfectly because 5htp helps you sleep and tyrosine gives me an energy boost. and to top it all off there is a root that help release more DOPAMINE and SERATONIN during the day in your brain. its is called RHODIOLA. so why dont you try the stack and see how everything changes?

[Breakthrough]

Very interesting post artur.

You have confirmed some of my recent experiences regarding dopamine and seratonin balance.Your posting could not come at a better time for me.

thank you

Breakthrough

[OffTheRadar]

i ll second that!!

5HTP hasnt really worked for me (see next thread) so maybe seratonin is not my problem. I intially thought it could be an issue because of some experiences with MDMA...back to the drawing board i guess!

[patricia]

artur that's a very interesting breakdown. my ? is how would you integrate rhodiola into the regimen you outlined and how many mgs? what you outlined is really helpful for me to determine what i shd take. thanks

[artur]

pretty easy. i take my rhodiola first thing in the morning. rhodiola contains rasovins, which is the active ingredient. you should get about 15-20mgrasovins a day. getting more or less for some reason diminishes the effect. i take 500mg of rhodiola once a day in the morning. it contains 3% rasovins which in total means 500mgrhodiola*3%=15mg. i personaly think 500mg rhodiola by NOW is the best. if you can find that brand then get it.
my antidepressive combination is this

FIRST THING IN MORNING
-tyrosine 3000mg
-SAMe 400mg
-Multivitamin
-Rhodiola 500mg @ 3% rasovins

RIGHT BEFORE BED
-5HTP 100mg
-Table spoon of essentail fatty acids
-Multivitamin

As for SAMe, im just testing it out to see the results, but everything else is a perfect natural mood booster/memory/cognitivity enhancer/energy booster/antidepressant/anti anxiety. and has many many more benifits to the body.

[patricia]

hi artur thanks again for the regimen. It is something that I'd like to incorporate. I am in my early 60s and have suffered with depression for 20 years, off and on okay periods under prozac and other meds which were shortlived, but now having exhausted all on the market do not want to deal with the after effects plus being dependent on them. I think the sjw will work to some extent but i think i need a boost with something else and will try your regimen. appreciate your input. patrice

[patricia]

artur one more thing. i see you are from ontario canada, i am in new hampshire usa. i did a www.NOW.com (http://www.NOW.com) and got some broadband company can you direct me to the NOW email?

[artur]

im sure you wanted their website not email: but i will tell you both
the website is http://www.nowfoods.com/
and to reach them just go to CONTACT US at the bottom of the page.

[patricia]

artur. As I see you are taking L-tyrosine with SAM, would there be a contraindication to me taking this with my Perika 300 mg in the a.m. and continuing with my other doses of perika in the afternoon and eve. I am on my 6th week of perika and not noticing anything truly significant.

[artur]

there will deffinatly be no contradiction with sjw and tyrosine.
i take tyrosine and SAMe because they work synergisticly. SAMe helps produce dopamine and norepinephrine and tyrosine is the building block of the two. i take rhodiola because it helps release norepinep[hrine and dopamine. so the three work perfectly together. from my research i found that to be the most synergistic combination. supplements like 5htp and sjw will make ur brain activity slower. u might feel confused and dissy at times. the ones i take are the complete opposite. but as for the negative interactions......i dont c any happeneing. i am positive they would amplify the effects of sjw. but i recommend rhodiola over sjw. anyways i can get carried away with typing. anymore questions i will b happy 2 answer

[patricia]

hi artur: thanks for the info. i think as soon as i finish my supply of sjw which is 30 days worth, i will opt for your tried regimen. you seem to have it figured out and why reinvent the wheel. appreciate your help tremendously. your information is invaluable to me.... going to florida be back on the 21st in case you answer this and do not hear from me promptly.

[busybeaver]

pretty easy. i take my rhodiola first thing in the morning. rhodiola contains rasovins, which is the active ingredient. you should get about 15-20mgrasovins a day. getting more or less for some reason diminishes the effect. i take 500mg of rhodiola once a day in the morning. it contains 3% rasovins which in total means 500mgrhodiola*3%=15mg. i personaly think 500mg rhodiola by NOW is the best. if you can find that brand then get it.
my antidepressive combination is this

FIRST THING IN MORNING
-tyrosine 3000mg
-SAMe 400mg
-Multivitamin
-Rhodiola 500mg @ 3% rasovins

RIGHT BEFORE BED
-5HTP 100mg
-Table spoon of essentail fatty acids
-Multivitamin

As for SAMe, im just testing it out to see the results, but everything else is a perfect natural mood booster/memory/cognitivity enhancer/energy booster/antidepressant/anti anxiety. and has many many more benifits to the body.


Artur,

As you stated your usage above and that gets you through. I have a few questions that might help me decide if this is right for me.

How long have you been doing this regimen for?
How much are you depressed or rather what was your diagnosis?
Is 3000mg of tyrosine too much to start or did you work your way up?
What is your regular diet - Vegan, chicken/fish/pasta, OR???
Do you regularly exercise?

I am sorry for asking so much, but am curious as each person has a different makeup, lifestyle, etc that they are in.

Being married with two kids, plus college, plus cub scouts, plus working full time (nights and weekends) - my time for me is pretty much spent and probably the reason the way I am (however I mostly link it to working the night shift and weekends). Our diet has been weaning off most red meats and we pretty much have grown our family into eating chicken/fowl, fish, veges, pasta...we try to cut out sweets as much as possible, but it's a slow process. Drinking is pretty much minimal due to time constraints as well as spending time with kids is more important!

Anyone else on their thoughts or what has helped them etc, would be glad to hear about it!

Thanks!

BB:freak4:

PS - I have been working into a 50mg dosage of HTP before bed with a b-complex supplement when I wake up which has wakened up my senses - WOW what a difference of waking up without a cloudy head! I am just starting to ramp up to 100mg in the coming week.

[patricia]

artur: well i did not obtain any significant benefit in the SJW, so am going to follow your regimen. How soon once you started taking it did you notice any change?

[roy100]

Just a suggestion, theres a lot of replies in this thread which have nothing do with the original post:

too much seratonin = depression? (http://www.sjwinfo.org/forum/showthread.php?t=726)

Its time to post new threads:rolleyes: